Arne Slot confirmed Liverpool have suffered a serious injury blow as Alisson was forced off during their 1-0 win at Crystal Palace.
The Brazilian goalkeeper has only recently returned to the line-up having struggled with a thigh issue last month.
But he looks set for another spell on the sidelines with an apparent hamstring problem, with the visibly furious 32-year-old punching the ground in anger, while having his head in his hand.
His injury forced Arne Slot into handing an unexpected debut for third-choice shot-stopper Vitezslav Jaros.
Usual back-up Caoimhin Kelleher missed the trip to south London due to illness.
And this saw Jaros, who has enjoyed four loan spells away from Anfield, replacing Alisson in the 79th minute for his first Liverpool senior appearance.
Jaros has spent time at Irish outfit St Patrick’s Athletic, Notts County, Stockport and most recently at Austrian giants Sturm Graz.
And he made an impressive cameo off the bench, where he notably denied Eberechi Eze after the England international ran clear on goal.
For Alisson, he will now surely withdraw from Brazil’s squad for their upcoming World Cup qualifiers against Chile and Peru.
Former Chelsea left-back Scott Minto fears the Reds No.1 could now miss handful of crucial games, saying during talkSPORT’s commentary at Selhurst Park: “You could see it as soon as he kicked the ball away.
“He sat down and started beating the ground with his hand – he knows that not just him coming off today, that’s a pulled hamstring.
“I’m worried for Liverpool, he could be off for a good few weeks.”
That could be a big worry for Slot, with Liverpool’s level in quality to take a significant step up following the upcoming October international break.
In their first Premier League match back, Liverpool host Chelsea in Merseyside.
Just three days later they travel to Germany to take on RB Leipzig in the Champions League, before pitting their wits against fellow title challengers Arsenal at the Emirates on October 27 – a ground they have lost at in each of the last two seasons.
Back-to-back games against Brighton in the Carabao Cup and league then follow, before Liverpool face Bayer Leverkusen and Aston Villa ahead of the November international break.
Slot conceded after the match that he expects Alisson not to play any of those games, and the Brazilian will likely return to action after the next international break in November.
He told TNT Sports: “It’s true that the fixtures are difficult, but I’ve also felt how difficult Wolves away and Crystal Palace away are, and it’s very good that we won these games, but now it’s up to us to show ourselves in the big games as well.
“Unfortunately Ali will not be with us in those matches, I assume, if I saw how he walked off the pitch.
Liverpool’s upcoming fixtures without Alisson
- Chelsea (H) – 20 Oct
- RB Leipzig (A) – 23 Oct
- Arsenal (A) – 27 Oct
- Brighton (A) – 30 Oct
- Brighton (H) – 2 Nov
- Leverkusen (H) – 5 Nov
- Aston Villa (H) – 9 Nov
“But it’s also good to see that with Caoimhin [Kelleher] being sick yesterday our third goalkeeper got this performance – it’s always nice for a team that everybody is involved in results.
“He [Jaros] was really good – he had a very good season last season, he won the league and won the cup in Austria, so we trust him a lot.
“He wanted to go [out on loan again this season] because he wanted playing time again, but we said, ‘Listen, at a club like this we also need a very good third goalkeeper’, and today proved we are right.
“And maybe for him it was a nice moment to make his debut for Liverpool.”