Consistent mistakes when playing out from defence were finally punished when Michael Olise curled home the opener.
Jean-Philippe Mateta swiftly tapped home a second to put Palace firmly in control, with Molineux silenced.
But Wolves recovered in the second half and responded to the home fans’ encouragement when Matheus Cunha dragged a goal back, with the help of a VAR check.
However, Wolves’ chances of a comeback were over when some more poor defending allowed Eberechi Eze to race through on goal and notch a third.